BBC Radio 4 program: Everything we know is wrong [30min]

"A highly influential paper by Dr John Ioannidis at Stanford University called "Why most published research findings are false" argues that fewer than half of scientific papers can be believed, and that the hotter a scientific field (with more scientific teams involved), the less likely the research findings are to be true. He even showed that of the 49 most highly cited medical papers, only 34 had been retested and of them 41 per cent had been convincingly shown to be wrong. And yet they were still being cited.

Again and again, researchers are finding the same things, whether it's with observational studies, or even the "gold standard" Randomised Controlled Studies, whether it's medicine or economics. Nobody bothers to try to replicate most studies, and when they do try, the majority of findings don't stack up. The awkward truth is that, taken as a whole, the scientific literature is full of falsehoods."

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