Weiss et al. used a representative sample of 973 twin pairs to test the hypothesis that heritable
differences in subjective well-being are entirely accounted for by the genetic architecture of the Five-Factor Model’s personality domains. Results supported this model
The researchers conclude that "geneticists interested in subjective well-being should focus their search for genes on those genes that influence personality". Given that the FFM explains under 20% of the variance in subjective well-being in the normal population I'm not so sure about this.
Weiss et al. (2008)
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